Lipid-coated nanoscale coordination polymers for targeted cisplatin delivery
نویسندگان
چکیده
منابع مشابه
Lipid-coated nanoscale coordination polymers for targeted cisplatin delivery.
Nanoscale coordination polymers (NCPs) containing a Pt(IV) cisplatin prodrug, disuccinatocisplatin, were formed by a surfactant-templated synthesis and were shown to have a prodrug loading of 8.2 wt% and a diameter of ~133 nm by dynamic light scattering. These NCPs were stabilized by coating with a DOPC/cholesterol/DSPE-Peg2K lipid layer; a release profile in phosphate buffered saline showed an...
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Nanoscale coordination polymers (NCPs) have been demonstrated as an interesting platform for drug delivery, as they possess many advantages over small-molecule chemotherapeutics, such as high payloads, lower systemic toxicity, tunability, and enhanced tumor uptake. Existing formulations for the delivery of methotrexate (MTX), an antifolate cancer drug, have very low drug loadings. Herein, we re...
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Chemical sensors for rapid detection of explosives are important for the versatile applications in security screening, industrial process control, and environment monitoring. Many explosive compounds possess electron withdrawing nitroaromatic groups, and often act as good electron acceptors. Electron donor conjugated polymers have been seen as one of the most promising candidates for detection ...
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ژورنال
عنوان ژورنال: RSC Advances
سال: 2013
ISSN: 2046-2069
DOI: 10.1039/c3ra42033g